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The hypothesis which is based on experimental data in rats and supports the notion that a single carcinogenic agent possibly interacts with two neighboring tissues, inducing the development of tumours of different histotypes in the same organ, remains to be substantiated in human tissues [ 25- 27].
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Although extensively researched in animals, isolated lung models have yet to be substantiated in humans.
Experimental models of diabetes have provided a range of novel molecular targets for this condition, but none have been substantiated in humans.
The evidence of renal tubule progenitors in human kidneys is quite compelling at present, but nevertheless remains to be substantiated in other mammalian kidneys.
This assumption should be substantiated in further research.
Anyhow, these results should be substantiated in larger cohorts.
Direct physical contact/presence of NBS1 on telomeres and their function in telomere maintenance has been substantiated in the case of humans but not in plants.
The microtubule-targeted antiproliferative activity of maytansine/maytansinoids was substantiated in a screening of 60 human cancer cell types by the U.S. National Cancer Institute [13].
This observation in patients has been substantiated in human/SCID mice chimeras of human prostate cancer tumorigenesis [ 73].
The association between enhanced levels of BAFF and autoimmune disease in humans has been substantiated in mice rendered transgenic or deficient for this cytokine.
These women are often publicly stigmatized, even if their allegations are substantiated in court.
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