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Genes with low correlation between their transcriptomic and proteomic levels could be substantially regulated by post-transcriptional mechanisms [ 22].
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The final value of the potential is substantially regulated by the biological system and is independent of the steel composition.
To determine if PLD1 activity is substantially regulated by phosphorylation, we measured the PLD1 activity using several PLD1-mutants including PLD1-WT, S505Q, S505E and S558A in the presence or absence of 25 mM glucose.
Dopamine levels are substantially regulated by its reuptake via the dopamine transporter (DAT) and by enzymatic degradation by catechol- O-methyl-transferase (COMT) or monoamine oxidase A (MAOA).
The activity of Pim2 is constitutive and its degradation does not seem to be substantially regulated.
However, it becomes increasingly clear that FA profiles are also substantially regulated by endogenous FA metabolism (44).
The Arctic is also already substantially regulated by domestic and international laws.
Thus, the extent of genomic DNA methylation in E. histolytica is likely greater than that indicated by the expression profiling as not all genomic regions that are methylated appear to be either transcriptionally silenced or substantially regulated by 5-AzaC treatment.
Fig. 3d shows the tPA level was substantially down regulated by transfecting astrocytes with tPA siRNA.
For example, sympathetic vasomotor tone has been shown to be tightly regulated by chemoreflex mechanisms.[35] Furthermore, MSNA is substantially increased in patients with obstructive sleep apnea [36], [37] and in patients with chronic obstructive pulmonary disease[38].
The remaining substantially up-regulated protein-coding genes might be directly regulated by the PRG-1 protein; the target genes of the small RNAs could regulate the other mRNAs.
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