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For most of the Obama Presidency many good pieces of legislation either languished in the Senate or had to be substantially changed as Democrats, despite holding a majority, needed 60 votes to get a bill passed.
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Further empirical studies have confirmed that even when the environmental geometry is substantially changed, such as by adding or moving walls, the position of place fields can be predicted on the basis of their position relative to the surrounding walls [48,50].
Since the diagnostic definitions of affective disorders were substantially changed in ICD-9 and ICD-10 as compared with ICD-8, only patients diagnosed with bipolar disorder according to ICD-9 or ICD-10 were included in the study.
The BMA is correct that the current proposals are inadequate as a basis for renegotiation, and until they are substantially changed then there is nothing to discuss.
Senate officials say there are probably 8to1010 other Democratic senators who feel as Mr. Levin and Mr. Kennedy do, and who would probably vote against a resolution unless it is substantially changed.
As Lowe contemplated the digital restoration of Nimrud, he noted that even the British Museum's lion was substantially changed from its initial state.
That may be true, Democrats and some Republicans say, if the tax package is substantially changed.
Later this picture was substantially changed.
No other results were substantially changed.
And viewing habits have substantially changed as children, teenagers, parents and grandparents scatter to different rooms to watch different programs.
Many job profiles could substantially change as a result of collaboration with computers and robots.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com