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15 However, it is well known that bulk phase relations can be substantially altered for nanoscale particles.
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In contrast, the interaction was substantially altered for aSyn1-110, a truncation mutant lacking Gly-Ala, and binding to this mutant was no longer saturable (extrapolated KD value >1 mM).
Management of these patients would be substantially altered accordingly if an invasive technique for nodal staging were unavailable [24], [25].
It took just 19 minutes for American history to be substantially altered this past Friday, July 19 , 2013
By design, the strength of the formwork may be substantially altered by permissible adjustments to configuration.
"Field surveys establish that all the buildings have been substantially altered from their original design," according to the EIR.
For example, people's actions may be substantially altering an intervention and thereby creating additional benefits beyond diarrhoea reduction.
While soil community structure is likely also to have been substantially altered in managed systems, evidence for shifts in biological diversity and function are more equivocal (McCaig et al. 1999; Jesus et al. 2009; Wallis et al. 2010; A. Bissett, A. E. Richardson, G. Baker and P. H. Thrall, unpublished data).
Coleridge Cottage, for instance, was substantially altered during the late 1800s, but several rooms have now been restored to resemble how they might have looked when Coleridge and his wife Sara were using them – including what is probably the original fireplace with the "thin blue flame" that he mentions in Frost at Midnight.
Moreover, there are no established serologic correlates of protection for pertussis vaccines, raising the possibility that regulatory agencies may require large, complex, and very expensive clinical efficacy trials if the production method for wP is substantially altered.
To the east is the kitchen and associated rooms, and further east are rooms used for administration offices, most of which have been substantially altered.
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