Doses should therefore be substantial so that treatment effects are not missed.
The instrument might be particularly useful in situations in which brevity and simplicity of administration are necessary, such as large epidemiological studies, or as in the case of the present parent study, where the scientific focus is not substance use, but where SUD comorbidity is expected to be substantial, so that data on substance use are very important.
They should also be substantial, so that they sit solidly.
While the normal model may be motivated by asymptotic arguments, in actual applications the number of estimates to be combined is commonly small [ 13, 14] and hence the estimation uncertainty in the between-study variance τ is substantial, so that an adjustment is appropriate and in fact improves operating characteristics [ 7– 15, 15].
So it is substantial money that cannot be ignored," Tourism Minister Najib Balala told the BBC.
Based on a chilling recent precedent, the risk is substantial that this so-called technical updating will spread far beyond what's said to be contemplated — and greatly expand the already expansive power of the government to spy on Americans.
The Ticketus statement said: "The court has made it clear today that the Ticketus contract cannot be breached unless there is substantial evidence that by doing so the administrators are able to significantly improve returns for creditors and improve the chance of returning the club to a going concern.
So far, there is substantial evidence that the activity of mitochondrial complex I appears to be amplified in breast cancer epithelial cells and its aberrant activity can profoundly enhance the progression and the aggressiveness of the disease [ 79].
"The revenue made from that is quite substantial so I think there is still a possibility for Google to recoup the investment made in developing the Android operating system," she suggested.
However, with the standard deviation of sometimes over 40%% of the average rounds and questions, there is substantial variability among runs so that gains can be small.
"It would seem that the area we've designated is the area where there could have been substantial debris and smoke and materials, so that's why we extended the geographical area," she said.
