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Non-response could be substantial in this study because drug use is illegal in China.
The impact of vaccination to prevent both S. pneumoniae and NTHi AOM may be substantial in this population and is worth investigating.
The impact of vaccination to prevent NTHi and S. pneumoniae AOM may be substantial in this population and is worth investigating.
At an economic level, this study did not estimate the loss of occupational activity and related social contributions due to breast cancer, which might be substantial in this disease.
However, we feel that population stratification is unlikely to be substantial in this population because: (1) the statistical tests were limited to Caucasian subjects only, and (2) we observed no evidence for a significant difference in the genetic background between cases and controls, based on a sample of 24 consecutive SNPs recently genotyped on chromosomes 1, 8, 11, 12, and X (data not shown).
Nevertheless, at a population level, with the combination of high overall prevalence of chronic disease and high proportion of low-income households in the very old, the total excess burden associated with low income is likely to be substantial in this age group.
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Conclusion: Medication use was substantial in this population.
Prevalence and burden of primary headache disorders was substantial in this community.
Although not usually chief complaints, incidence of embarrassment was substantial in this sampling.
Toxicity and most importantly neutropenia with associated infections were substantial in this study.
The differences between the respiratory and fermentative species are substantial in this part of the pathway.
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