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This can have varying levels of complexity depending on the trait, which then relates to the cost of phenotyping, which can be substantial for complex drug effects (such as neuropathy or liver toxicity).
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However, the advantages of a benefit-harm comparison metric may be substantial, for example, in the context of complex situations where multiple outcomes are important and where patient, provider, and policymaker preferences vary [ 7].
Costs were substantial for the poor.
The situation is complicated by the fact that the general question of when a convention, or rule of any kind, is in force for a speaker, is substantial and complex (cf. Pagin 1987: Chpt. 1).
However, this opportunity presents challenges that are substantial and complex.
But however complex the details, the effect of the change would be substantial, and in pushing for it Mr. Obama has kicked a hornet's nest.
It can be substantial.
Here is substantial money for AIDS.
"There is substantial room for improvement".
There are substantial further questions for research.
But what's good about it is substantial and subtle enough for you to want the rest of it to be more complex yet.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com