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This gain in efficiency can be substantial especially when there are patients not complying with their assigned treatments.
The bias could be substantial especially when data are sparse [ 23, 24].
This study has shown that opportunity costs of community-based health insurance may be substantial, especially when they rely on government health workers and district managers.
Testing fees can be substantial, especially when individual genetic variants are assayed sequentially, and indeed are soon likely to rival the cost of obtaining an entire genome sequence.
These estimates are also prone to random error, which can be substantial, especially when survival experience between small populations is compared.
The costs of multiple medications can be substantial, especially when older patients fall into the "doughnut hole" of Medicare Part D coverage.
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Unfortunately, your costs can be substantial, especially if you need a lot of health care.
Several studies have shown that the magnitude of bias from loss to follow-up is potentially substantial, especially when SES is the exposure of interest (Howe et al. 2013; Weuve 2013; Weuve et al. 2012).
In practice, the number of initially balanced confounders could be even larger and residual confounding due to omitting all these variables from the adjustment model may become substantial, especially when these variables are strong risk factors for the outcome.
The impact of caregiving on caregivers' quality of life (QoL) is substantial [ 3- 7], especially when experiencing a significant burden [ 8, 9], restricted roles and activities, and increased psychosomatic, anxious, or depressive symptoms [ 1, 10].
Level of civil unrest was substantial when this study was carried out, especially in Ghazni.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com