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The difference VAT makes can be substantial, as a document on Bupa's website entitled "Economic Attractiveness: home chemotherapy" illustrates.
The long-term economic impact of this outbreak also is expected to be substantial as a consequence of long-term rehabilitation and disability costs (8 ), possible risk for chronic kidney disease (9 ), and risk for premature death in severe cases (10 ).
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Paul Johnson, head of the Institute for Fiscal Studies thinktank, added: "A £3bn tax on the payrolls of companies with pay bills over £3m is substantial, as is an increase in stamp duty land tax of nearly £1m on second homes and buy-to-let properties.
The wine list here is substantial, as are prices.
This is substantial as a merit, and one of the strongest attributes of the model.
However, the increase of cost and time for such experiments could be substantial as we used a large number of time points to represent all key time points of stripe rust infection.
When that happens, the rewards can be substantial, as Cunningham discovered when a song she co-wrote aged 17, Too Little Too Late, became a million-seller for US singer JoJo.
But their sound was substantial, as you would expect from an organization with a formidable tally of international competition awards to its credit.
Yet all of them were substantial, both as intellectual performance and as a challenge to conventional assumptions about movie form and routine reviewing.
Inpatient costs related to mental illness are substantial, though declining as a percentage of overall mental health treatment costs.
Others contend that the dissimilarities are substantial, such as the apparent absence of an economic contract involving king, vassal, and serf.
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