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DCs can be subdivided into subsets, characterized by specific surface markers and functions [ 23].
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The probes present in a 'platform – T7 primer' dataset were subdivided into subsets based on the motifs they contain.
They can be subdivided into different subsets and to fully understand their functions in the tumor microenvironment, DC subsets should be examined individually with regard to influences on their behavior, dependent on different local factors.
In fact, it is unlikely that RA itself is a single disease, but instead may be subdivided into various subsets (for example, RF-seropositive and RF-seronegative) with distinct etiologies.
However, it now appears that Treg are a heterogenous population within CD4+ T cells, and that a subset of CD4+CD25+ T cells could be subdivided into different functional subsets based on expression of novel markers such as GITR, Foxp3 or neurophilin-1 (Cosmi et al, 2003; Ramsdell, 2003; Bruder et al, 2004; Ronchetti et al, 2004).
Some significant differences existed among the other species but they cannot be subdivided into mutually exclusive subsets.
In mice, transitional B cells can be subdivided into two developmental subsets, T1 and T2, based on expression of CD21 and IgD.
According to the confidence limits (95% CI) obtained by the bootstrapping procedure, Chromis sp, D. aruanus, P. pavo and S. nigricans could be differentiated statistically from each other in pairwise comparisons, but they cannot be subdivided into mutually exclusive subsets by length.
Human NKT cells can be subdivided into CD4+ and CD4− subsets, which display functionally distinct cytokine secretion profiles [27], [28], [35].
T-helper cells may be subdivided into Th1 and Th2 subsets.
In this fashion, CD4 T cells can be subdivided into different T helper subsets such as Th1, Th2, Th9, Th17, and Th22 and regulatory T (Treg) cells [ 10].
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