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This design is approved by Cochrane for use in systematic reviews of interventions " that cannot be randomized, or which are extremely unlikely to be studied in randomized trials" [ 28].
It may be that some clinical conditions dealing with potentially life-threatening problems should not be studied in randomized prospective clinical trials containing an OBS/NoRx arm.
Delphi uses a series of anonymous questionnaires designed to develop a consensus of opinion and can provide guidance on topics that have not or cannot be studied in randomized controlled trials.
Whether or not a distinction in predictors exists can only be studied in randomized controlled trials aiming at investigating the effectiveness of multidisciplinary treatment in patients with CWP.
Preliminary studies of bevacizumab's efficacy in neovascular macular degeneration suggest benefits similar to those of ranibizumab [ 4], so its "off label" use might continue, or it might be studied in randomized controlled clinical trials of patients with macular degeneration (and eventually licensed for this indication if found to be effective), or the price of ranibizumab might be reduced.
Effectiveness of hip replacement, at least for the less severe cases of osteoarthritis, should be studied in randomized trials, as findings from observational studies will remain uncertain due to potential for confounding by indication, by other baseline differences, and due to other potential biases related to observational studies.
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The appropriate indication and agent selection of the antipsychotics should continue to be studied in prospective, randomized, controlled trials.
Obesity is an emerging problem in Pakistan and it should be studied in greater detail with larger, randomized, well-funded generalisable studies.
Surgical removal of CNV in AMD has been studied in a randomized, controlled trial and was found not to be better than observation alone with regards to maintenance of vision (SST 2004a, 2004b).
Patients with non-Hodgkins lymphoma undergoing autologous bone marrow harvest were studied in a prospective, randomized fashion.
However, the efficacy and safety of VTE prophylaxis in thermally injured patients continue to be elusive as it has never been studied in a prospective, randomized fashion.
More suggestions(15)
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be proven in randomized
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