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Naturally, synaptic compartments can only be studied in brain or cultured neurons and are thus not included in the earlier studies where the subcellular localization of the active γ-secretase complex was determined using non-neuronal cells.
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Application of AMT-PET has also been studied in brain tumor imaging: AMT is accumulated in various brain tumors, and kinetic AMT-PET parameters are able to differentiate various brain tumor types, assess glioma proliferative activity, and estimate IDO and tryptophan 2,3-dioxygenase expression in both gliomas and meningiomas [27 32].
Hence, the endogenous antioxidants such as SOD, CAT; non-enzymic antioxidant – ascorbic acid and TBARS levels in were studied in brain, kidneys and adrenals.
To test that the vesicle mobility recorded in cultured astrocytes also occurs in vivo, vesicle dynamics was studied in brain slices in which cell-to-cell contacts are preserved and tissue architecture is closer to the one present in the brain (Potokar et al., 2009).
To substantiate observations made in AD brain in an animal model of AD, the temporal and spatial appearance of pE-Aβ was studied in brains of APP transgenic Tg2576 mice at the age of postnatal month (PM) 10, 12, 14, 16, 18 and 23.
Your experience of being human – from thoughts to actions to pathologies to sensations – can be studied in your individual brain with some benefit.
Therefore the effects of cognitive interventions on brain activity changes are studied in the brain of healthy older persons and in the brain of older persons suffering from pathological aging.
Lazaroids, established antioxidants and neuroprotectants, have been studied in several brain pathologies.
mRNA of inflammatory marker genes was studied in different brain regions.
Leptin expression was studied in multiple brain sections of control and LS-injected rats.
However, for many of these genes neither baseline neuroanatomical nor injury-related temporal expression have been studied in the brain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com