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The PAZ-domain containing pAgos are predicted to directly destroy virus or plasmid nucleic acids via their nuclease activity, whereas the apparently inactivated, PAZ-lacking pAgos could be structural subunits of protein complexes that contain, as active moieties, the putative nucleases that we predict to be co-expressed with these pAgos.
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Among identified mitochondrial proteins, 12 are structural subunits of the electron transport chain complexes localized in the mitochondrial inner membrane.
BAF60a, BAF60b and BAF60c are structural subunits of the BAF complex that bind to the core ATPase Brg1 to provide functional specificity.
Vassel's protein, REV7, is a structural subunit of one key translesion polymerase, and its expression is deregulated in many different cancer cells.
REV7 (shown in purple) is a structural subunit of one key translesion polymerase, which aids in DNA damage repair.
Cytidine is a structural subunit of ribonucleic acid that consists of cytosine and the sugar ribose.
The 40S ribosomal protein S3a is a structural subunit of the ribosome involved in protein translation in the cytoplasm [ 19].
Smc3p is a structural subunit of the cohesin complex and had a previously identified Ctf phenotype (Michaelis et al. 1997; Haering et al. 2002).
TUBA1A is a critical structural subunit of microtubules that is transiently expressed during neuronal development (15).
Comparatively rare mutations are also found in genes for structural subunits of cIV, such as COX6B1 (27) or COX7B (28), as well as those encoded in mtDNA (29– 31), plus genes required mainly or exclusively for the biosynthesis of mtDNA-encoded cIV subunits [e.g. LRPPRC (32), TACO1 (33)].
Cytolysin has been shown to contribute to virulence in animal models of enterococcal infections, and cylL, encoding one of the structural subunits of enterococcal cytolysin was present in 16/31 of the isolates by PCR.
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