The causes of long-term ENSO variation are still being explored, but changes in solar radiation owing to Milankovitch variations are strongly implicated by modeling studies.
This region has been strongly implicated by association studies and is known to contain regulatory elements.17 Currently, two resequencing studies have been reported;18,19 however, only the coding regions were examined.
The cortical targets of the BLA that we found were modulated by PTSD, including pregenual ACC/dorsomedial PFC and dACC, and are strongly implicated in PTSD by behavioral and cognitive challenge tasks (Milad et al, 2009; Morey et al, 2009).
These routes of infection have been strongly implicated in pig infection by nipah virus and horse infection by hendra virus, both viruses belonging to the Paramyxoviridae family [55], [56], another family of Mononegavirales (enveloped single-stranded viruses with an RNA monosegmented genome of negative polarity and capsids with helical symmetry).
The 28mer peptide (MBP102 129), which contains the epitope MBP111 119, was digested in vitro by 20S immunoproteasomes in presence or absence of PA28-αβ, which is strongly implicated in MHC-I antigen presentation by increasing the production of some epitopes [30], [31].
A previous study also indicated that extracellular signals induced by VEGF-A are strongly implicated in EMT in human pancreatic carcinoma cells [37].
Interestingly, the dopamine neurotransmitter pathway has been strongly implicated in the depression-like behaviours exhibited by WKY rats.
BRCA1 is strongly implicated in the maintenance of genomic stability by its involvement in multiple cellular pathways including DNA damage signalling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis.
The association between these probe sets and NK cell function was supported by literature searches; of the 141 probe sets identified by QTA, 108 (77%) were strongly implicated in NK cell function (additional file 3).
In addition, both FOXO4 and SP1 have been strongly implicated in the regulation of gene transcription initiated by insulin in skeletal muscle [ 27].
