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Many PKs can be strongly activated by the phosphorylation of the activation loop, and dephosphorylation can block the substrate access to the active site.
Interestingly, the enzymatic activity of PARP1 can be strongly activated by treatment of cells with ROS such as hydrogen peroxide [ 8].
ASK1 assays were straightforward and we found ASK1 to be strongly activated by ischaemia in the perfused rat heart, with a gradual increase in activity during ischaemia, reaching maximal activation at 45 min (Fig. 5A).
Thus, we hypothesized that the aPKCλ/FoxO1 signaling axis might be strongly activated in angiosarcoma.
The paraventricular thalamic nucleus (PVT), the most dorsal component of the thalamic midline, is known to be strongly activated following a variety of stressors and thus might be suggested to play a role as a relay for stress-related information targeted for viscerolimbic areas in the brain.
In the laboratory, application of 'inflammatory soup' causes increased trigeminal sensitisation and increased responsiveness so that dural afferents can be strongly activated by mechanical and other stimuli that initially had evoked little or no response.
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PPARγ activity is strongly activated by 12∶0 and 18∶2 and weakly activated by 18∶1 and 16∶0 [16∶0
Akt, which in turn controls mTORC1 activity, is strongly activated by SCF in UT7 cells.
The DLPFC was strongly activated in load manipulation, whereas activation as a function of delay was restricted to the left premotor regions and Broca's areas.
The enzymatic activity of PARP is strongly activated in cells in response to treatment with ROS such as H2O2 [15].
JNK was strongly activated by HGF, reaching maximal activation as early as 5 10 minutes after HGF addition (Fig. 3C).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com