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On the other hand, the MD method requires the inference of the missing state at each gapped site (or the summation of the likelihood for all four nucleotides at the gapped sites), a process that is bound to be strained with increasing number of gaps in the alignment.
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You are, in fact, much more likely to be straining with your ear-trumpet at new movies by Michael Mann and Martin Scorsese with their mumbling mobsters and wise guys.
Even though they seem to be straining, with new names that sound more like luxury cars than lifestyle pills, new drugs -- Lexapro and Cymbalta -- will soon pack the shelves next to Zoloft, Paxil, Prozac, Effexor, Celexa and Wellbutrin.
Regional relations have been strained, with Zimbabwe, Malawi and Mozambique organising for some citizens to return home.
And relations were strained with its biggest customer, Britain's Ministry of Defence (MoD).
Relations had long been strained with Bligh, who had accused the corps of corruption and ineptitude.
Relations between the group's members had previously been strained, with Stipe telling an interviewer in 2003 that in 1998 only an emergency meeting saved the band.
Hashemi Rafsanjani in the early 1990s, but his relations were strained with reformist president Mohammad Khatami, who served from 1997 to 2005.
Google's relations with the major record companies have often been strained, with the labels accusing Google of not doing enough to curtail piracy.
Only 10 years ago, relations between Syria and Turkey were strained, with Turkey accusing Syria of sheltering Kurdish separatists and Syria lashing out at Turkey over water and territorial disputes.
Sixtus IV's relations were strained with France, whose king Louis XI firmly upheld the Pragmatic Sanction of Bourges (1438), which had established the liberties of the French Church.
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CEO of Professional Science Editing for Scientists @ prosciediting.com