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IFN-α2b will be stopped in case of grade 4 haematological toxicities.
The study can be stopped in case of significant excess morbidity/mortality in the alternative treatment arm.
In addition, study medication will be stopped in case of pregnancy, and the participant will be withdrawn.
The trial will not be stopped in case of futility, unless the DSMC during the course of safety monitoring advices [sic] otherwise.
The occurrence of grade ⩾2 WHO toxicity prompted a THAL dose reduction, whereas drug administration was to be stopped in case of ⩾3 WHO toxicity.
The whole study was to be stopped in case new therapeutic regimens with superior benefit of either therapy arm were published, if the interim analyses showed that the criteria for stopping the study by using the methods of Pocock (1978) and O'Brien and Fleming (1979) were reached and when the number of patients recruited was clearly below the expected value.
Similar(52)
eThis sequential re-initialization process is stopped in case the best solution found for both problems does not improve for more than three consecutive iterations.
These ideas would be compromised, if ERA testing was stopped in case the LoC was not exceeded already at a lower tier (e.g. a laboratory study), because then any uncertainties regarding environmental risks would be dismissed already at this early step of the ERA.
Treatment was stopped in case of intolerable toxicity or disease progression.
Oxaliplatin was stopped in case of grade 3 or 4 peripheral sensory neuropathy.
Chemotherapy was stopped in case of symptomatic heart failure and creatinine serum level >150 μmol l−1.
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