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The pre-calcific stage is characterized by metaplasia of tenocytes into chondrocytes that can be stimulated by multiple factors including hypoxia, microtrauma, disuse and hormonal action.
Src activation can be stimulated by multiple tyrosine kinases such as EGFR, VEGFR, PDGFR and FGFR.
NKG2DL expression is highly restricted in healthy tissues, but can be stimulated by multiple stimuli, including infection and heat shock, and by cellular transformation [ 12].
At the transcriptional level, almost all IAP proteins are driven by the upstream transcription factor NF-kappa B (NF-κB), which can be stimulated by multiple stimuli, including TRAIL [ 19].
Autophagy is a tightly regulated pathway, which can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, ROS, DNA damage, protein aggregates, damaged organelles or intracellular pathogens [ 12].
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JNKs are stimulated by multiple factors, including cytokines, DNA-damaging agents, and environmental stresses, and are important in controlling programmed cell death or apoptosis.
Moreover, the expression of VEGF can enhance the expression of other proangiogenic factors and their receptors; thus, vessel outgrowth is stimulated by multiple factors [ 95, 97].
The autophagy response, where proteins and defective organelles are degraded by lysosomes, is stimulated by multiple forms of stress: starvation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, and pathogens [ 6].
IP-10 expression is stimulated by multiple signals downstream of the T-cell signals, mainly IFN-γ and tumour necrosis factor-α, but also interleukin (IL -2, type IL -2Ns, IL-27, IL-17/IL-23 and IL-1β [ 6, 8– 10], supportype pathogen specIIIFNsdaptive immune responses by a positive IL-17/IL-23 IL-17/IL-23 IL-17/IL-23
We are hard-wired to be stimulated by such goals.
That's going to be stimulated by the private sector".
More suggestions(18)
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