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The presented analysis suggests that structurally conserved hotspots in the kinase catalytic domain may be statistically enriched by mutations with a high probability of being cancer drivers.
These two pathways could not be statistically enriched by the seed genes, providing additional evidence that atBioNet can identify novel mechanisms related to the studied disease.
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(C and D ) Biological processes identified by Gene Set Enrichment Analysis to be statistically enriched in Cry1-associated complexes (C ) or Cry2-associated complexes (D ).
KEGG pathways with corrected p values ≤ 0.05 were considered to be statistically enriched in common carp.
Sixty-five pathwere were found to be statistically enriched with the down-miR targets, whereas only four pathways were enriched with the ctrl-miR targets.
Eight out of nine functional modules are statistically enriched beyond what is expected by chance (P < 0.05, Fisher's exact test, except for other processes).
One such revised motif is present in all major subtypes of HIV proteins known to be phophorylated by ERK1/2, and is statistically enriched among the substrates of ERK1/2.
Chromosomal regions previously implicated in Wilms' tumor by cytological evidence are statistically enriched in predicted WT1 targets.
An online version of the GeneMerge program [ 40] was used for ORA to identify whether particular biological processes or molecular functions, as defined by GO annotations, are statistically enriched in the set of differentially expressed genes in the sis7-1 mutant compared to the wild type [ 41].
One of these candidate motifs, Dc, was statistically enriched among the binding partners of ERK1/2.
Since ERK1/2 substrates were statistically enriched with MAPK docking motifs, we hypothesized that the presence of these docking sites on most sequences of HIV proteins MA, Nef, Rev, Tat, and Vif would explain their reported phosphorylation by ERK1/2.
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