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Nanoparticles for medical application should be stabilized by modification with hydrophilic or hydrophobic molecules in order to prevent aggregation in water or organic solvent, respectively [15].
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The nanoporous PS thin film template was stabilized by modification of substrate using hydroxyl terminated PS so as to enhance the adhesion with substrate for following electroplating process.
Additionally, peptides are synthetically accessible and can be stabilized by chemical modifications.
As reported by Floess et al. (2007) and Tao et al. (2007), FOXP3 expression must be stabilized by epigenetic modifications such as complete demethylation of a highly conserved region within the noncoding region of FOX3 and acetylation of lysine residues in the forkhead domain by inhibition of HDACs.
One structural class of lead compounds in our cathepsin K inhibitors program is based on an arylaminoethyl amide scaffold, which has potential metabolic weak points that might be stabilized by appropriate chemical modification(s).
If it is a consequence, then gene repression caused by chromatin modification may be stabilized by DNA methylation.
Adr1 promoter-binding may be stabilized by interactions with coactivators [32], and post-translational modification may regulate this interaction.
Y2H might not detect interactions that are dependent on post-translational modifications or that should be stabilized by the presence of another protein.
To determine if MEKK1 is ubiquitinated, we questioned whether the modification found on MEKK1 would be stabilized by a deubiquitinase inhibitor, such as N-ethylmaleimide (NEM).
They may be stabilized by the addition of gelatin.
44 EMT can be stabilized by autocrine TGFβ signaling.
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