It has long been speculated that molecular chaperones are able to accelerate the evolutionary rate of their clients under the direct buffering hypothesis (Bogumil and Dagan 2010; Lachowiec et al. 2013).
The molecular mechanism behind the action of monomeric TRAP on adipogenesis is unknown, but it can be speculated that TRAP is recognized by a surface receptor on pre-adipocytes and that signals from this receptor regulate adipogenesis.
It is speculated that Hsp90 as molecular chaperones play an important role in signal transduction and stress management in C. nankinginse.
But it has been speculated that due to its molecular weight it is expected to be filtered through the glomerulus but not through low-flux hemodialysis membranes; so dialysis clearance can not be the reason of lower levels in HD patients [ 25].
Primary cilia are increasingly being recognized as cellular 'antennae' which sense and transduce signals from the microenvironment, particularly through Wnt and Sonic hedgehog signaling, and based on previous studies in Xenopus and zebrafish, it has been speculated that cilia can function as molecular switches between canonical and non-canonical signaling pathways [ 34, 35].
While it has been speculated that DNA methylation defects cause this disease, little is known about the molecular function of CDCA7 and its functional relationship to HELLS and DNMT3b.
It is speculated that the first and seventh cysteines of the LMW-GS form the inter-molecular disulfide bond, while the rest form three intra-molecular disulfide bonds [ 30, 31].
Based on this difference in color, it is speculated that TX-cut does not react further with the polyaldol species and thus does not increase the molecular weight further like the PyGas wash does.
Although it has been speculated that alternative HER receptor activation mediates resistance to targeted therapies, this is the first time that a molecular mechanism is provided to explain drug resistance in breast cancer cell lines.
It has been speculated that BUBR1 antagonizes Aurora B at the kinetochore to promote chromosome alignment at the metaphase plate, but the molecular mechanism has remained unknown.
