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It could therefore be speculated that individuals carrying a specific set of risk alleles clustering in specific pathways (for example in IRGM, ATG16L1 and NOD2 – all implicated in autophagy), and maybe having been/being exposed to a same environmental factor(s), end up developing CD.
It may be speculated that individuals and families with this kind of hypersensitivity problem develop coping strategies built on cooperation and communication with those around and between family members.
Based on the results of this study, it may be speculated that individuals with a preponderance of the G allele of the polymorphism react more strongly to stress with a higher production of PRL [ 170].
It may also be speculated that individuals without university education are more excluded from the labour market today or that health literacy has become more central in the health care system.
It may be speculated that individuals with high SEP could be less likely to accept the side effects of AD treatment, since they have the possibility to pay for costly alternatives such as psychotherapy.
From an evolutionary standpoint, it may be speculated that individuals that display a high level of physical activity have an advantage in habitats that require relatively large home ranges or territories (for example, for food and/or partner seeking), provided that they are cautious, exploratory, and stick to routines at the same time.
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Given that the reward circuit in the brain shows elevated responses to mere visual perception of foods [15], [16] and that this circuit interacts with the attention systems during the perception of food targets [19], it can be speculated that individual differences in the reward circuit's responses to foods could account for the observed effects.
Moreover it could be speculated that individual randomization could have been a better option to control for co-factors affecting screening uptake.
It may be speculated that individual patients might benefit from differing doses of CRRT; however, there was no suggestion that specific groups benefited in subgroup analysis of the ATN and RENAL trials, indicating that identification of such patients may be difficult.
It has been speculated that individual TA systems may respond to specific stresses and play a role in biofilm and persister cell formation, as well as having numerous other putative functions.
NF-1 has been shown to activate transcription [24] and it can be speculated that in individuals with rs490683-GG genotype, where the NF-1 half site is intact, GHSR expression is enhanced, thus potentially leading to an increase in receptor signalling and ultimately to an increase in appetite [28].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com