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Furin processing and transport to the cell surface might be specifically increased in tumor cells, as response to increased need to process cell matrix components required for tumor proliferation and tissue invasion.
DOI: http://dx.doi.org/10.7554/eLife.05116.009 The DNA content increases in sporadic AD neurons raised the question of what genomic loci may be specifically increased in AD.
Another marker shown to be specifically increased in PCa epithelia, compared to benign epithelia, is α-methylacyl-CoA racemase (AMACR or P504S) [ 89– 91].
Interestingly, MIF was found to be specifically increased in CF patients, perhaps suggesting a unique role for CD74 or CXCR4 in the mechanism of CCSP+ cell recruitment.
6 15 Quantitative RT PCR experiments showed the level of expression of the Atoh1, p27kip1 and p57kip2 genes to be specifically increased in double-mutant mice (figure 5D).
Although cleaved caspase-3 was not detected in the non-infarct myocardium, significant increases in the infarct area confirmed the presence of apoptotic cells and suggest that Brn-3b(l) may be specifically increased in injured myocardium.
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MMP-2 was specifically increased in the spleen.
The TAZ locus is amplified in 27 of 313 breast tumors, and TAZ mRNA expression was specifically increased in the tumors with the amplification [66].
GSC similarity was specifically increased in post-vaccine GBMs, and correlated best to vaccine-altered gene expression and endogenous anti-tumor T cell activity.
Here, we report for the first time that iOPN protein levels are specifically increased in the right cortex early after transient global cerebral ischemia/reperfusion (15/45 min) in rats, suggesting a role for the protein as a responder to stroke-induced cell damage.
Other plasma proteins that were specifically increased in tumor-bearing mice included acetyl-CoA acetyltransferase 1 and 3, fatty acid binding proteins 1 and 4, fibulin, peroxiredoxins 1, 5 and 6, SPARC, and thrombospondins 1 and 4. We next analyzed the altered plasma proteins from each confounder condition.
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