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We might also have missed AMPs because some might be specifically expressed at other stages, for instance in larvae or adults.
We found high levels of Jagged-1 to be specifically expressed at arterial remodeling zones where SM-MHC+ cells were developing and in CAs.
This was highlighted by the many members of the homeodomain TF family, including Hox members that play a critical role in developmental patterning and were found here to be specifically expressed at the planula stage.
Moreover, foxj1, an F-box TF and a key regulator of motile ciliated cell differentiation programs in different model organisms such as flatworm, fish and mammalian systems [ 29, 30, 34], was found here to be specifically expressed at the planula stage.
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Interestingly, Wnt9/10, Wnt11a, and a transcript variant of Wnt3 were specifically expressed at the medusa stage, whereas Wnt 16b expression was specific to early strobila.
OsMEL1 also has a duplicated partner, OsAGO14, located on chromosome 7 that does not show any expression in vegetative tissues and is specifically expressed at stages beginning from P3 in panicles and until S2 stage in seeds.
BNIP2 and Cdc42GAP homology (BCH) motif- containing molecule at the carboxyl-terminal region 1 (BMCC1) gene is specifically expressed at high levels in favorable NB samples, indicating that BMCC1 expression may be a favorable prognostic factor for NB.
To identify genes that are specifically expressed at certain times of the cell cycle, we analyzed global gene expression in synchronized cells.
In contrast, GlNCED1 was specifically expressed at higher levels in developing flowers when petals start appearing.
ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically expressed at high levels in hepatocellular carcinoma.
Prodrugs can also be activated by enzymes that are specifically expressed at a higher level in tumors, leading to a selective anti-tumor effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com