Although these genome-wide profiles indicate that nucleosome occupancy is generally affected by Chd1, they do not reveal which subsets of genes are specifically dependent on Chd1 function, and what the molecular basis of this dependency might be.
This bos1 activation was specifically dependent on the production and secretion of the PelB and/or PelC pectate lyases.
Indeed, we found that the terminal differentiation of adult-generated hippocampal granule neurons is specifically dependent on PC3/Tis21 expression, being impaired in mice ablated of PC3/Tis21.
This demonstrates that our correlation to physical structure is specifically dependent on the pairing of identified coevolving residues and not the result of single-site biases.
This effect was specifically dependent on DJ-1 inactivation, as TAT-α-syn maintained almost unchanged its protective effect against oxidative stress in the presence of a siRNA negative control (CT-) and when the DJ-1 protein level was restored by exogenous addition of TAT-DJ-1 2h before the oxidative challenge [Figure 3B].
Inhibition of NMDA receptors blocks LTP and LTD induction, although recent studies using pharmacological NMDA receptor subtype blockade approach has proposed that LTP induction is specifically dependent on activation of NR2A-containing receptors and LTD requires activation of NR2B-containg receptors [39], [40].
As shown in Fig. 1B, migration of MDA-MB-231 cells cross HUVEC monolayers was significantly blocked by anti-E-selectin antibody, but not by inhibitory antibodies against LFA-1 or VLA-4 (Fig. 1B), suggesting that metastasis of breast cancer cells across TNF-α pre-activated HUVEC monolayers is specifically dependent on HUVEC E-selectin.
This class of interactors may be important for responses that are specifically dependent on Smad3.
We performed rescue experiments to confirm that the induced apoptosis was specifically dependent on the suppression of SNW1 expression.
Our results demonstrate that DNA-PKcs protein stability is specifically dependent on the PARsylation activity of tankyrase 1.
