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This is due to the fact that sialylated structures can prevent cell-cell interactions through non-specific charge repulsion, but they can be specifically bound by cell adhesion molecules, such as selectins [ 5].
Regions of the genome determined to be specifically bound by CaRF were downloaded using the GALAXY [25] platform based on genome coordinates.
By contrast, H1.4 has been found to be enriched in heterochromatic regions [ 7], and methylated H1.4K26 but not H1.2K187 can be specifically bound by HP1 [ 20], a main component of heterochromatin.
However, H3 K36me3) could be specifically bound by the Tudor domain of Phf1, and in the context of the nucleosome, this interaction enhanced transcription factor binding through increased site exposure.
Recent studies have shown that AREs can be specifically bound by complexes of several basic-leucine zipper transcription factors, including NRF2 (Ishii et al. 2000; Moi et al. 1994).
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Both double-stranded and single-stranded telomeric DNA regions are specifically bound by proteins that regulate telomeric DNA replication by telomerase.
One of the two upstream ERE sequences was specifically bound by ERα-containing protein complexes, in vitro, in gel shift analysis.
Of six wild type oligonucleotide sequences used as probes (see material and methods), only two probes (probe 2 and 6) were specifically bound by in vitro synthesized Cdx4 protein (A.S. data not shown).
While the unmutated L1ICD was specifically bound by 14-3-3ζ 14-3-3ζ 14-3-3ζathen S1181Aly reduced and the RSLESD deletion abolished 14-3-3ζ binding (Fig. 2C, upper panel), indicating that 14-3-3 binding to L1 indeed requires the RSLESD sequence and that this binding is critically dependent on Ser1181.
These data indicate selective recognition by HP1: H1.4K26me2 is specifically bound by HP1 whereas H1.2K187me2 is not.
The Neh2 domain contains the two degrons that are specifically bound by Keap1.
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