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Nevertheless, the analysis of DNA or RNA from patients can permit us to assess genes that may be specific targets of certain cytotoxic agents and others that may be markers of multidrug resistance.
Nevertheless, the analysis of DNA and RNA from patients' serum can permit us to assess genes that may be specific targets of certain cytotoxic agents and others that may be markers of multidrug resistance.
Most of the identified bands corresponded to ribosomal proteins from both the large and the small ribosomal subunits (Table S1 and data not shown), suggesting that the ribosome or at least ribosome components could be specific targets of 6AP and GA.
In particular, up-regulated target genes were found to be specific targets of down-regulated miRNAs in gastric cancer.
Spots specifically reacting with auto-antibodies from the sera of pancreatic ductal adenocarcinoma patients, which were analyzed by mass spectrometry, corresponded to metabolic enzymes or cytoskeletal proteins which proved to be specific targets of the humoral response to pancreatic ductal adenocarcinoma.
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In C. elegans, certain superoxide dismutase (sod) genes are specific targets of either DR or IIS, while other sod genes are targets of both pathways [4].
Importantly, increases in the levels of mRNAs encoding four members of the E2f family are observed along with numerous genes that are specific targets of E2f3 (Table 3).
Interestingly, both S100A11 and S100A6 are specific targets of S100B [ 55], which is involved in neural plasticity [ 56].
Consistently, the expression of cyclin A (Fig. 4B) and cyclin E (Fig. 4B), which are specific targets of E2F1, paralleled the levels of acetylated E2F (Fig. 7).
Earlier studies have shown that both XIAP and cIAP-1 are specific targets of SH122, and knockdown of XIAP/cIAP-1 resulted in significant TRAIL-sensitization.
However, whether coding mononucleotide repeats (cMNR) in PTP genes are specific targets of frameshift mutations in MMR-deficient colorectal tumors is still unknown.
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