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This suggested that C13 and C85 were more likely to be specific modulators of SG formation but not the other types of cytoplasmic granules.
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Interestingly, glutamatergic neurotransmission is closely controlled by intracellular levels of polyamines, spermine and spermidine being specific modulators of NMDA and AMPA receptors activity [92] [97].
Thus, neurotransmitters are specific modulators of certain immune functions.
During the last years, it became evident that hormones and neurotransmitters are specific modulators of cells of the immune system by fine-tuning their activation and key functions.
In this study, we demonstrated that these observations do not reflect a uniform activation by non-REM sleep, but that high amplitude widespread slow waves present during this state are specific modulators of epileptic activity.
Currently, there are no specific modulators of HIFs or PHDs available for clinical use.
Besides its modulator effect on opioid receptors (Galeotti et al. 2002), menthol has recently been shown to be a specific modulator of ionotropic inhibitory receptors.
In mammals there are a total of seven FXYD proteins including phospholemman (FXYD-1), of which all but FXYD-6 have been shown to be tissue-specific modulators of Na, K-ATPase [ 3].
IMP is a specific modulator of umami taste (Yamaguchi 1991).
However, current attempts at reducing neuroinflammation mediated via microglial activation have only been partially efficacious, possibly because of the fact that such strategies are general inhibitors of inflammation rather specific modulators of the inflammatory versus phagocytic phenotypes of microglia.
Several studies have described the iron-binding antioxidant properties of albumin [ 38], which is also a specific modulator of cellular glutathione and an important antioxidant [ 39].
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