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Hepatocyte-specific antigen was used to identify CTCs and is considered to be specific for normal and neoplastic hepatocytes.
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RASSF1A and p16 both seem to be specific for SGTs and not normal parotid tissue although they did not meet robust statistical significance.
The TBG-siCK2 nanocapsule has been shown to be specific for malignant and not normal prostate cells in culture, and a similar TBG-RNAi-CK2 nanocapsule has been shown to be specific for malignant and not normal tissues in mice [ 1- 3].
Hypermethylation of the CpG islands, located near the 5′-termini of host-genes for SNORD123, SNORA70C, and SNORA59B, was established to be specific for cancer cells, compared to normal human cells.
MGMT, VGF, CCNA1 and FKBP4 are interesting, as they could be specific for tumours as all of the normal samples showed no methylation, and in addition, hMLH1 that had only one positive in normal.
P16 and RASSF1A are interesting as they could be specific for tumors as all of the normal samples showed no methylation.
Science 339, 1219 1224 (2013).This work identified an endogenous population of thymus-derived Treg cells that infiltrates mouse prostate tumors and is specific for a normal prostate antigen, and demonstrated that Aire-mediated expression of peripheral-tissue antigens can drive the generation of tissue-specific Treg cell subsets.
This analysis therefore shows that the molecular signatures we have identified are specific for the tissues (normal or tumour) they have been selected to represent.
The ability of TNFα to inhibit ANGPTL-4 expression was specific for RA FLS because normal HSF stimulated with the same concentration of TNFα exhibited a strong induction of ANGPTL-4.
In child and adolescent psychiatric research a procedure like this is often used to clarify the question if discrepancies from a normal sample are specific for a special diagnostic group or if they are a characteristic of mental disorders in general.
Tumor antigens may not be specific enough for discrimination from normal host cells.
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