DNA methylation in melanoma was specific for distinct H3K27me3 peaks rather than for broadly covered regions.
Ultimately, however, such filtering should rely on more quantitative scoring schemes that are specific for distinct experimental methods (40) and can be generalized across different organisms.
Another important outcome of this study is that we demonstrate that alterations in energy/redox metabolism, which are specific for distinct environmental toxins, are not bystanders to energy failure but also contribute significantly to cell death progression.
Our study clearly demonstrates that alterations in energy metabolism, which are specific for distinct mitochondiral/environmental toxins, are not bystanders to energy failure but also contribute significant to cell death progression.
This analysis resulted in the prediction of 12 novel families of toxins and 13 novel families of antitoxins including families that are specific for distinct groups of archaea or bacteria, in particular, thermophiles.
By clustering breast carcinoma expression profile datasets using only the genes that are specific for distinct fibroblastic tumors, we can observe subsets of cancer that contain different fibroblastic subtypes in the tumor stroma.
It is likely that some expression patterns will be specific for clinically distinct disorders within the autoimmune category.
(Note that this question does not arise for eukaryotic clamp loaders, whose five subunits are distinct and can be specific for their requisite binding site).
In the future, recognition of the distinct TME types in breast cancer could lead to targeted therapy that is specific for the distinct TME-based subtypes of breast cancer.
The selected SNP markers that were specific for only the most distinct population are expected to have low heterozygosity.
