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Two stochastic search algorithms are employed in [19] that permit solutions to significantly larger networks (having up to a few thousand vertices) to be solved within reasonable time and without significant resources.
In each case, the central element of the solution searching algorithm is a standard multi-load structure optimization problem, which using an appropriate method, can be solved within reasonable time.
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Special emphasis is placed on the concept that drug discovery projects are typically directed at a key protein target whose structure must be solved within a reasonable time frame to have an impact on the drug discovery process.
However, most of these effects, like other constraints or functions, could be added to this approach as well: nearly the only aspect that needs to be taken into account is the size of the mathematical model (otherwise it cannot be solved within a reasonable time frame).
Most questions could be solved within 15 min.
It was solved within seconds".
"The process wouldn't have been solved within weeks or months".
The multi-level lot-sizing (MLLS) problem is a combinatorial optimization problem which can only be solved optimally within reasonable delays when small instances are considered.
Many problems in the operations research field cannot be solved to optimality within reasonable amounts of time with current computational resources.
This problem is NP-hard, although in practice fairly large instances can be solved to optimality within reasonable running time.
Restated, it is hard to be solved in a reasonable time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com