Unlike membrane-bound receptors, which tend to have a rapid signal transduction process (e.g., the opening of a membrane channel, the phosphorylation of a protein), the signal transduction process for ligands of nuclear hormone receptors is slower and involves a specific pattern of gene expression.
Assessment of root traits in crop breeding material can be slow and expensive, involving a combination of field-, glasshouse- and laboratory-based screens (Clark et al., 2011).
Therefore it might have been easier to obtain a capital conviction against Mr. Muhammad in Maryland but more difficult to execute him there since its courts are thought to be slow and skeptical where capital punishment is involved.
Anyone who said, "Hey, I know horse-drawn carts are slow and inconvenient and involve wading through a lot of crap, but people are nostalgic for a simpler time, so let's call off the race to make a greener car and replace it with a buggy revolution" would be laughed out of Elon Musk's office.
But it didn't happen all at once; the process was slow and painful, involving many budget deals that were extremely difficult, politically.
The process of trimming government budgets is slow and cumbersome, involving notifications to unions about temporary furloughs, reductions in overtime pay and cuts in grant financing to state and local programs.
The process is slow and complicated and involves fees at different levels. .
Word of mouth (or other forms of person-to-person communication, such as text messaging) thus becomes the vehicle for underground public opinion in totalitarian countries, even though these processes are slower and usually involve fewer people than in countries where the media network is dense and uncontrolled.
Our process was slow and careful and also involved sharing a lot of pain.
Single particle analysis methods that provide correlated size and intensity information on many individual nanoparticles in a population would be ideal, but these approaches can be slow, labor intensive, and involve complex and often custom instrumentation that is not suitable for widespread use.
