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Reverse phase protein arrays (RPPA), a miniaturized dot-blot immunoassay with low sample input requirements, allow for many samples to be simultaneously interrogated for the presence of a single protein target, and the method has found utility in clinical trials.
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Nevertheless, this finding highlights the power of an unbiased deep sequencing approach by not only facilitating detection of the viral pathogen but also enabling elements of the host response to be simultaneously interrogated, thus generating new hypotheses for analysis of host-pathogen interactions.
A multiparametric approach with the current range of imaging techniques allows functional aspects of tumours to be simultaneously interrogated.
The diagnosis sites were simultaneously interrogated using a multiplex PER and the results were confirmed by fragment sequencing.
The advent of high-throughput hybridization-based assays can allow the methylation status of around 14,000 genes to be analyzed simultaneously (although only a few CpGs are interrogated for each gene) and strategies based on second generation massively parallel sequencing technologies will undoubtedly provide a more complete assessment of RCC epigenetics and elucidate novel RCC TSGs.
In addition to evaluating for an intrauterine pregnancy, the pelvis should be interrogated for evidence of free fluid.
Gene Ontology (GO) terms allow gene lists to be interrogated for the overrepresentation of specific biological processes.
Specific candidate signalling pathways will be interrogated for their ability to influence lytic osteoclast formation.
Another drawback of this approach is that only expressed probe sets are interrogated for SNP discovery.
Vita was detained at the airport; he was searched and interrogated for six hours.
Two of those on board were interrogated for several hours by police before being released.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com