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Paradoxically, however, the third PDZ domains of both proteins, PSD95 and SAP97, appear to be significantly more selective toward natural ligands than one would expect from their rather promiscuous interactions with artificial ligands (compare Fig. 1 and Fig. 3).
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Data for Gram-positive anaerobic bacteria showed that SMT19969 was significantly more selective in its activity than fidaxomicin.
Thus, although the caspase-2 specificity of the Ac-VDTTD-AFC peptide in cell extracts was not absolute, this reagent was significantly more selective for caspase-2 than the commonly used Ac-VDVAD-AFC peptide.
Since α particles, by comparison with β particles, have a much shorter path length as well as a much higher LET, they are significantly more selective and potent in killing targeted cells (McDevitt and Scheinberg, 2002).
23 Silodosin was about 280 times more selective for prostate tissue than for splenic tissue and about 50 times more selective than for thoracic aortic tissue, which shows that silodosin is significantly more selective for prostate tissue compared with other α1-adrenergic receptor antagonists.
I think it will be significantly more.
Others say it could be significantly more.
It can also be significantly more expensive.
We have previously shown that viral escape is significantly more rapid (higher selective advantage) in primary infection than in chronic infection [30]; this is also a feature of the dataset studied here (P = 0.003, Mann-Whitney two-tailed) which has considerable overlap with the earlier dataset.
Patients with cardiometabolic comorbidities were significantly more likely to be dispensed selective NSAIDs (7.9% vs 5.5%), colchicine (17.6% vs 15.6%), corticosteroids (22.5% vs 19.1%) and allopurinol (32.6% vs 31.2%) than gout patients with no comorbidites (all p < 0.0001 after adjusting for age).
However, aripiprazole users were significantly more likely to be concomitantly treated with a selective norepinephrine reuptake inhibitor (p<.05).
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