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Only the GO or KEGG categories reported to be significantly enriched by several enrichment tools in a gene list were considered as consistently overrepresented.
They can be significantly enriched through reinforced strategic intelligence and sense-making processes.
(miscellaneous oxidoreductases and oxygenases [63] was identified to be significantly enriched (p = 1.4×10−3).
Although DNA motifs were identified none appeared to be significantly enriched.
We found 164 GO gene sets to be significantly enriched in the aged stroma (FDR<25%.).
All endothelial categories were found to be significantly enriched in the endothelial data, and all neuronal categories were found to be significantly enriched in the neuronal data (q<0.25; Table 3).
If the data are reproducible in the second platform, the category should be significantly enriched in the predicted direction.
As an example, the CDK5 signaling pathway, was found to be significantly enriched (p = 0.00009) for proteins identified only in the pooled CFS proteome.
It is interesting to note that the cartilage gene set taken from another published microarray screen failed to be significantly enriched in our growth plate comparisons [23].
In particular, hypomethylated DMRs were found to be significantly enriched for Pol3 binding.
Consistent with this, we found ECM hubs to be significantly enriched in highly promiscuous domains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com