With regard to mAb therapy, the defucosylated versions of AHM have been established and the synergistic effects have been shown when combined with Len.
In metastatic malignancies model, a significant efficacy of the GRP94-based gene/immunotherapy strategy was shown when it was combined with radiation therapy [20].
No synergic effect on sheep digital flexor healing was shown, when PRP was combined with peripheral blood MSCs (PBMSCs) [ 109].
This effect has also been shown when oxaliplatin and irinotecan were combined in fluorouracil-resistant colorectal carcinoma, as compared to their single-agent activity (Scheithauer et al, 1999).
While the combined result of the German Austrian studies so far has revealed no statistical improvement regarding OS [ 81], a survival benefit was shown when the results from these studies were combined with the results from the Italian trial [ 93].
In colorectal cancer, it has been shown that, when combined with 2-weekly oxaliplatin, administered dose intensity of capecitabine can be increased without additional toxicity when compared to the standard 3-weekly schedule.
The development of therapeutic strategies that can completely and precisely match the complexity of breast cancer with equally complex combinations of regimens will be clinically challenging, particularly considering the need to utilize combinations of drugs that must be shown to be safe when combined together.
It was shown that Ag85B-TB10.4, when combined with a cationic liposome adjuvant, induced a powerful cell-mediated response [12], IFN-γ producing CD4 T cells and protective immunity in mice challenged with Mtb [13].
This approach has been shown particularly effective when combined with genome-wide microarray genotyping or conventional linkage analysis to identify regions of homozygosity in consanguineous pedigrees [ 3- 7].
The goal is to develop and implement a Chronic Disease Management Program for diabetes intensification which includes the four factors that have been shown to work when combined together; provider education, patient education, clinical practice guidelines and disease measurement [ 56].
