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Using flow cytometry and cell proliferation analyses, it could be shown that expression of the ZHER2 00477-KDEL fusion construct in the SKOV-3 cell line resulted both in a marked reduction in cell surface level of HER2 receptors and that the cell population doubling time was significantly increased.
However, using a sensitive detection method to detect CTLA-4 on the surface of activated T cells with a sensitivity of less than 200 molecules per cell, it can be shown that expression is independent of the proliferative history of the cell and is exclusively dependent on the time elapsed since the onset of activation of the T cell [ 11].
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It was shown that expression complexity is positively correlated with both coding and intronic content of the gene [ 28, 62].
However, as the function in direct space here are real, it can be shown that expressions (13) and (14) are indeed real; the fact that i appears in these expression insures this fact (see Appendix/Fourier Transforms).
Earlier, it was shown that expression of exogenous GFP can be effectively inhibited by long GFP dsRNAs expressed from RNA polymerase II promoters [17] or GFP shRNAs expressed from the U6 RNA polymerase III promoter [18].
More recently, it has been shown that expression of oncogenic PIK3CAH1047R in oncogene-driven normal lineage-restricted mouse mammary cells causes cell dedifferentiation and development of multi-lineage mammary tumors10,11.
It has been shown that expression of the E6 or E7 genes of HPV often increases stress sensitivity [14] [17].
Recently, it was shown that expression of interferon stimulated gene 15 (increasescreases in human cells with short telomeres [11].
It has previously been shown that expression of this system is sensitive to environmental conditions [24], and that its level of expression varies between different bacterial strains [92].
In vivo it was shown that expression of a mutant FtsZ that was predicted to stabilize the polymer could overcome the effects of MinCD overexpression [42].
Previously it was shown that expression of SPANX-A/D genes is restricted to the normal testis and certain tumors [2] [4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com