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Using clinically relevant doses of doxorubicin and ZA, inhibition of tumour growth was shown to be sequence dependent with doxorubicin followed by ZA, leading to inhibition of tumour growth associated with evidence of enhanced tumour cell apoptosis and reduced proliferation.
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In vitro studies suggested that the synergy between irinotecan and 5FU is sequence dependent, with a higher cytotoxicity when irinotecan is administered before 5FU (Guichard et al, 1997; Mullany et al, 1998; Mans et al, 1999).
Although nucleotide misincorporation was not found in vivo, the frequency of single-nucleotide deletion was observed to be sequence-dependent, with mutation frequencies ranging from 1 to 26%.
The type of mutation is sequence-dependent with a larger proportion of mutations occurring in reiterated sequences.
The flexibility and deformability of native DNA has been extensively studied, 16,25,46,49 and it is well established that both features are sequence-dependent, with base composition and the presence of specific sequences substantially contributing to the malleability of the double helix.
The effects of ZD1839 with cisplatin and/or 5-fluorouracil were sequence dependent (P<0.003), with the best results achieved when ZD1839 was applied first.
Such situations arise in one-machine minimum penalty job sequencing problems when setup times are sequence dependent.
However, this was sequence dependent.
TLS1 and TLS2 activities appear to be sequence-dependent.
Such an effect would be sequence-dependent.
The results indicated that haematological toxicity was sequence-dependent: the median neutrophil nadir was lower with paclitaxel given first (964× 10 l−1) than with cyclophosphamide given first (1864×10 l−1864×10
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