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Biochemical potency depends on receptors that have been designed by evolution to be sensitive to subtle changes in chemical structure (for example estrogen vs. testosterone, or epinephrine vs. norepinephrine) whereas the hERG channel has been designed to transport potassium and has had little or no evolutionary pressure to be selective against micromolar concentrations of aromatic amines.
This allows the camera to be sensitive to subtle changes in shadow (e.g., a planarian moving along the dish's edge) despite large variations in overall light levels perceived by the animals in different quadrants and dishes.
We suggest that BAE mitochondria are highly sensitive to these quinone compounds, but that the exact magnitude of ROS generated may be sensitive to subtle differences in conditions from experiment to experiment or in groups of experiments carried out at different times.
However, the studies many not be sensitive to subtle effects that could be relevant for disease risk.
CSF markers may also be sensitive to subtle 'subclinical' CNS injury which may have longer-term consequences.
It should be noted that the CMS model was shown to be sensitive to subtle variations in design and, thus, has a poor interlaboratory reliability, particularly in rat studies [ 75].
Similar(52)
Invariably, the users of a technology are sensitive to subtle issues that nonusers fail to appreciate.
We developed the first version of a computer vision system that is sensitive to subtle changes in the face.
As a group of ligand-induced proteins, different subtypes of mammalian Notch (Notch1-4) are sensitive to subtle changes in protein levels.
Realizing that my facial skin was sensitive to subtle differences in emission of heat from various combinations of light beams, I came to correlate and memorize the patterns of heat and action established during rehearsal and used this knowledge to maintain correct changes of position during filming.
These derived hypsometric attributes are sensitive to subtle changes in overall watershed development as mass is removed by erosion over a long geological time period.
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