This indicates that even though differential expression of Ccl2, Chka, Thrb and Synj2 are sensitive endpoints of chronic PCB126 exposure, as evident in their responsiveness at 30 ng/kg/day PCB126, these changes do not manifest themselves following 13 weeks of subchronic exposure to 1000 ng/kg/day PCB126.
If this relationship reflects a casual mechanism then our data suggests that neurocognitive performance may be a sensitive endpoint of cadmium toxicity in adults and that the WHO/FAO reference level may not protect against this effect.
Other end-points, such as oxygen transport variables, D O2, cardiac index, V O2, lactate, base deficit, and mucosal gastric pH, are all more sensitive endpoints of cellular resuscitation [ 65].
Be sensitive of a lag in interpreting.
Likewise, the clinical endpoint for these trials should be sensitive to the detection of product-related differences.
Each new environmental contaminant poses the challenging quest for sensitive endpoints of toxicity.
In prior risk assessments kidney damage has been considered the most sensitive endpoint of cadmium toxicity and reference levels for urinary cadmium have been established to protect against this effect (EFSA 2009: 1 μg Cd/g creatinine, WHO/FAO 2011: 5.24 μg Cd/g creatinine) [ 1, 10].
Recent risk assessments have established urinary cadmium reference levels to protect against kidney damage (EFSA 2009: 1 μg Cd/g creatinine, WHO/FAO 2011: 5.24 μg Cd/g creatinine), as this has been considered the most sensitive endpoint of cadmium toxicity [ 1, 10].
All tools assessed in our current study were sensitive as early-warning endpoints of dyes toxicity on zebrafish early life stages, and suggest that the CEA assay might be useful to predict effects on locomotor activity when cholinergic damage is absent.
If the calculation is based on caloric demand and a sensitive endpoint of reproductive toxicity, many IEFs tend to be about 1, indicating that humans are generally not more susceptible to reproductive toxicants than laboratory animals.
