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The pharmacokinetics and biodistribution investigations indicated DOX could be selectively released from PX in cancer cells triggered by the local overexpressed PLD, and PX could significantly prolong the half-life of DOX in the tumors and decrease the distribution in heart and kidney.
Additionally, Smac can be selectively released from mitochondria in the absence of an apoptotic stimulus, and, indeed, in healthy cells, cytosolic Smac has been described, produced either as an alternatively spliced variant whose maturation has been shown to bypass mitochondria or through other less well-defined processes [ 33, 34].
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Therefore, our finding that miR-451 is selectively released from malignant mammary epithelial cells in culture and in the body may be of importance for diagnostics.
We found that miR-451 and miR-1246 were selectively released from four breast cancer cell lines tested, whereas the release of these miRNAs from nontumorigenic MCF10A cells and unrelated normal fibroblast cell line IMR90 was much lower (Figure 4).
Specific endogenous miRNAs, most notably miR-451 are selectively released from HEK293T cells in EVs by a process that may involve Ago2.
If any anterior tibial component lift-off at 90° of flexion was noted, the tight PCL fibers were selectively released from the proximal tibia until lift-off no longer occurred.
The phenomenon that some components are selectively released from WPB has already been show in vitro [ 32] and deserves further attention in in vitro studies of differential regulation of WPB exocytosis.
Eosinophils produce dozens of mediators which may be selectively released and which have varying physiologic actions.
Both adsorbed and covalently bound aromatic and quinoid compounds are selectively released by the treatment.
These were selectively released by digestion with trypsin for 2 5 min at room temperature.
But the odds on favorite answer has always been selectively release crime statistics based on an ever changing metric.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com