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KATP blockers for the treatment of migraine should be selective for the Kir6.1/SUR2B subtype because of its dominant presence in vascular tissue (Table 1).
CGX-1007 (Conantokin G), a 17-amino acid polypeptide isolated from the venom of Conus geographus, is a novel NMDA receptor antagonist that is thought to be selective for the NR2B subunit.
Such substrates can be deemed to be selective for the target enzyme and can therefore be use for HTS.
We demonstrate here that ABPs need not be selective for the target of interest but can bind many related targets.
This is consistent with previous studies, in which the 1E6 monoclonal was found to be selective for the 85 90 kDa isoform of palladin [10], [18].
Two requirements must be met, however, to make such an inhibitor potentially useful in drug-adjuvant therapy: (1) despite the structural homology between APHs and ePKs, an inhibitor should be selective for the bacterial resistance enzymes.
Similar(40)
Using recombinant kinase panel screens, we demonstrated that each sensor was selective for the intended kinase and furthermore this selectivity translated into selectivity in cell lysates.
The electrode was selective for the F− ions by several orders of magnitude.
The solvent is selective for the polyolefine blocks of the copolymers.
This solvent is selective for the middle poly ethylene/butylene) block of the copolymer.
Docking studies showed that the compound 11d was selective for the inhibition of PDE-5.
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