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However, the most obvious impact of TEs is due to their mobility, and the polymorphisms they generate are a rich source of genetic variants that can be selected during evolution.
On the basis of this observation, they proposed that codon usage might be selected during evolution to synchronize the efficiency of translation with the functional requirements for the expression of specific proteins at certain times (Najafabadi and Salavati 2008; Najafabadi et al. 2009).
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These loci may be directly under selection, but more likely mark regions of the genome that have been selected during evolution, because some candidate loci clustered in the same chromosomal regions, such as outlier 17 and 18, and outlier 30 and 31 (Table 5; Figure 5).
Because natural products have been selected during evolution to bind to various proteins during their life-cycle, they are good starting points for drug discovery [3, 4].
Leaf structural features contributing to the maintenance of the high CO2 concentration in the chloroplast stroma may have been selected during evolution (Dunbar-Co et al. 2009).
Çağatay et al. (2009) use a synthetic biology approach to show that fluctuations or noise in protein levels may play a key role in determining which network design is selected during evolution.
Ultimately, this motif may have been selected during evolution because it is an efficient structural motif for modifying eukaryotic membrane fusion and thus contribute to pathogen survival.
This strategy has not been selected during evolution, possibly because Drosophila do not encounter in the wild at high enough a frequency bacteria that are resistant to the humoral immune response.
Natural products have been selected during evolution to interact with biological targets and their high degree of chemical diversity make them attractive as lead structures for discovery of new drugs [4].
Two possibilities, not mutually exclusive, may account for this observation: First, as one distinct advantage of regulating transcription elongation is to allow rapid gene induction in response to extrinsic signals, genes that are regulated in this manner may have been selected during evolution to have shorter length, in order to further accommodate the need for accelerated transcription.
This synergy makes the process mutually-beneficial, which is why grouping is selected during evolution.
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