Similar lesions could be seen in brains examined acutely that sometimes resulted in unusual tissue repositioning leading to dramatic alterations of cerebral architecture.
The researchers, led by Dr. Nora D. Volkow, director of the National Institute on Drug Abuse, urged caution in interpreting the findings because it is not known whether the changes, which were seen in brain scans, have any meaningful effect on a person's overall health.
In general, the magnitude of the fold-change in term/pathway enrichment was larger in the set of negatively regulated genes, also in agreement with what was seen in brain.
In humans, high expression of PEG10 in adult tissues was seen in brain, kidney, lung, testis and weak expression in spleen, liver, colon, small intestine and muscle [2], [9].
Exposure to DES showed similar results as with E2 i.e. esr1 expression was increased in liver, but, in addition, increased expression levels of esr1 were seen in brain of female fish (Figures 6A B, 7A).
No changes though were seen in brain carnosine levels.
Low expression was seen in brain, lung, spleen, liver and heart.
Increased expression of FABP7 was seen in brain tissues after systematic administration of a neurotoxin, kainic acid [ 14].
