We also propose that previously reported menopausal cognitive decline, presumed to be hippocampally mediated, may be secondary to executive dysfunction.
Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis).
However, it is possible that proinflammatory consequences of PS1 mutation may also be secondary to PS2 dysfunction [13] because studies have demonstrated that mutant PS1 can interfere with PS2 function or alter the dynamics of PS2 γ-secretase complex assembly [64], [65].
Postural hypotension may be secondary to autonomic dysfunction.
This may be secondary to hypothalamic dysfunction or increased metabolic clearance as a result of central obesity.
Decrease in CMAP amplitude and increase in duration were suggested to be secondary to the dysfunction of energy-dependent sodium-potassium pumps in muscles [ 23].
There are incentive motivation processing abnormalities in first-episode psychosis; these may be secondary to dopamine dysfunction and are not attributable to generalised cognitive impairment.
We suggest that this impairment may be secondary to dopamine dysfunction, though we acknowledge that, as yet, no direct evidence has proved that performance on the CRRT is dopamine dependent.
CS was defined as systolic blood pressure <90 mm Hg for ≥1 h not responsive to fluid administration alone, thought to be secondary to cardiac dysfunction, and associated with signs of hypoperfusion or cardiac index ≤2.2 l/min/mm2 and pulmonary capillary wedge pressure >18 mm Hg [ 9, 10].
Changes in blood glucose levels may be secondary to gastrointestinal motor dysfunction, as occurs in diabetic gastroparesis, which may be compounded by similar findings described in CD.
