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A decrease in the ATP concentration, as measured by a luciferin/luciferase coupled assay, occurred within 20 min of XCT 790 exposure, suggesting that the observed AMPK activation may be secondary to deregulation of energy production.
In addition, decreased levels of CMA proteins LAMP-2A and Hsc70 in PD brain samples were found to be secondary to deregulation of several microRNAs that regulate LAMP-2A and Hsc70 expression [ 124].
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