For example, CA12, a highly correlated gene with estrogen receptor α (ERα), is robustly regulated by estrogen via ERα in breast cancer cells, and this regulation involves a distal estrogen-responsive enhancer region [ 24, 25].
Importantly, the genes whose expression was perturbed upon serine-273 phosphorylation were known to be relevant in metabolic regulation but did not necessarily belong to the "canonical" genes that are robustly regulated by PPARγ agonists.
It is certainly possible that more than nine hepatic genes are robustly regulated by estrogen in the analyzed species/conditions.
In fact, it was found that YAP/TAZ is robustly regulated by many GPCRs and their cognate ligands [ 27].
To the best of our knowledge, we provide the first evidence that Shh expression is robustly regulated by thyroid hormone in the brain.
MTF-1 in vitro is robustly regulated by zinc but not by cadmium ions, as just published [ 46],and further confirming that labile zinc displaced by cadmium is the primary mediator in MTF-1 activation.
Despite the absence of several mammalian adipokines (i.e., LEP, TNFA, RETN, PAI-1, APOE, and ITLN1) and metabolic enzymes (i.e., LIPE), adipogenesis and lipid metabolism in the chicken are robustly regulated by mechanisms that are, for the most part, similar to those described in mammals.
It's the task of governments everywhere to hold the line, to see such activities are robustly regulated, their entrepreneurs honoured when they do well by society as well as themselves, jailed if they commit fraud, condemned when their legal manoeuvres are transparently immoral as some of King Phil's have been – despite protests of injured innocence.
Biomolecules are robustly regulated from their transcription to their destruction to generate high fidelity control of cell physiology.
Expression of the morphogen Shh and its receptors is robustly regulated in the embryonic and adult mammalian brain following maternal or adult-onset thyroid hormone perturbations.
