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At present, the uses of miR for these purposes are still in their infancy and remain to be rigorously validated in clinical studies.
However, the field of molecular prognostication can be fraught with the risk of inaccuracy, and promising results must be rigorously validated in prospective studies before incorporating the use of such markers into standard practice.
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However, none of the proposed pathomechanisms has been rigorously validated in patient tissue.
To date, these estimates have not been rigorously validated in those with augmented clearances, resulting in potentially inaccurate drug prescription.
Although several mathematical models have been developed to correlate the RRT dose given on different schedules (i.e. intermittent (IRRT) and continuous (CRRT)), none of these models have been rigorously validated in clinical practice [ 17- 19].
The Institute of Medicine (IOM) report says that so-called "omics" tests diagnostic tools based on molecular patterns are highly prone to errors; it recommends they be rigorously validated before being used in clinical trials.
NGS carrier screening assays must be rigorously validated, both analytically and clinically, before entering the clinical laboratory.
Ideally, these parameters must originate from empirical data, and the system's (significant) dependence on these parameters must be rigorously validated.
Advanced methods of individual risk assessment must be rigorously validated before treatment strategies can be tailored to a patient's unique molecular profile.
Unfortunately, these cell models have not been rigorously validated and in some cases similar models produce dissimilar predictions [ 9– 12].
A new product line of PrecisonAb Antibodies has been rigorously validated for use in Western blotting.
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