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In addition, we also hypothesized that fully manifested hepatic steatosis could be reversed by reducing the fat percentage in the diet of obese mice.
Studies on thymus-hormone interactions have shown that thymic involution and T lymphocyte deficiency of aged male rats could be reversed by reducing testosterone levels through surgical castration [ 25] or by administering the antiestrogenic agent tamoxifen [ 26].
It was found that Na+/Ca2+-exchanger (NCX -mediated Ca2+ efflux was sigNCX -mediatedhanCa2+by fleffluxde and that the effects of flecainide on wase frequency could be reversignificantlyng [Na+]o, suggenhancedn important downstream role for NCX function.
However, recent work has demonstrated that Cx43 is linked to TMZ resistance, which can be reversed by reducing Cx43 expression (Gielen et al., 2013; Munoz et al., 2014), thereby supporting a therapeutic approach based on reducing connexin levels.
The rationale for expecting improved recovery after MIS could be questioned, because muscle atrophy and weakness developed during years of OA and inactivity might not be reversed by reducing the operative trauma only.
In addition, the increase in adiposity resulting from high fat diet feeding cannot easily be reversed by reducing body weight when switching back to chow feeding; mice retained the increased number of adipocytes that were accumulated during high fat diet feeding, although adipocyte volumes were reduced (Shi et al., 2009).
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Reverse engineering helps reduce the complexity of verification/analysis by partitioning the circuit into smaller parts.
Interestingly, these alterations were reversed by reducing plasma FFA, suggesting a causal role of high plasma FFA on altered β-cell function.
24 25 We have found that diabetes-induced myocardial dysfunction in a diabetic hypertensive rat model was reversed by reducing the AGE burden consequent to treatment with AGE-breaker.
In order to silence the FLC locus, the influence of the chromatin modifiers is reversed by reducing H3 histone methylation at lysine 4 and 36 and increasing methylation at lysine 27.
S-nitrosation correlated with inhibition of all three enzymes, and these decreases in activity were reversed by reducing S-nitrosothiols with DTT (Supplementary Figure S3) and by treatment with copper II) and ascorbate, which is selective for the reduction of S-nitrosothiols.
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