Sentence examples for be reversed by expression from inspiring English sources

This can be reversed by expression of the catalytic telomerase subunit of human telomerase reverse transcriptase (hTERT), demonstrating a critical role of WRN in the process of cellular senescence by maintaining the integrity of telomeres [9].

To further explore this hypothesis, we examined whether the increased levels of β-synuclein is regionally selective and whether the increase in β-synuclein levels in α-synuclein null mice could be reversed by expression of human α-synuclein.

Progressively, chronic endoplasmic reticulum stress contributes to hepatocarcinogenesis (13), and this steatotic ACOX1 null phenotype can be reversed by expression of the human ACOX1b isoform (8, 13).

These functions appear to be related to the function of PrP in neurons because they can be reversed by expression of PrP in neurons using a neuron-specific transgene [ 4].

Since the specificity of siRNA has always been a concern in knock-down experiments, it would be more convincing if the cytotoxicity could be reversed by expression of siRNA-resistant full-length Notch receptors.

Furthermore, the increased cell-cycle entry and increased proliferation of PKD2-null TCR transgenic thymocytes can be reversed by expression of active GFP-tagged PKD as judged by the impact of retroviral expression of a GFP-tagged catalytically active PKD on DP numbers and the cellular DNA profile of DNs from P14 PKD2−/− TCR transgenic mice.

Inhibition of bacterial growth induced by the toxin was reversed by expression of the cognate antitoxin or by the transfer-messenger mRNA (tmRNA).

These phenotypes were reversed by expression of a UAS-Pngl transgene, demonstrating that developmental defects were indeed due to the lack of functional Pngl.

Furthermore, the increased attachment rate observed in LRP-1-deficient cells was reversed by expression of a dominant-negative form of JNK-1 (Fig. 7B).

TPAP is a cytoplasmic enzyme that is essential for spermatogenesis in mammals; TPAP-deficient mice display an arrest in spermatogenesis [8], a phenotype that is reversed by expression of TPAP as a transgene in deficient animals [18].

Importantly, the impaired degradation of Aurora A after RNA interference of Plk1, was reversed by expression of a RNAi-resistant Plk1, indicating that the observed effects are specific for Plk1 (Suppl. Fig. S2C).